Lecture Overview

Understanding circulatory dynamics accurately and “controlling” them as a therapeutic strategy is fundamental to the treatment and management of cardiovascular diseases, from acute circulatory failure to chronic heart failure. Our group integrates circulatory physiology, systems control engineering, and digital twin technologies to develop mathematical models based on circulatory theory, create high-precision circulatory simulation environments, and translate these achievements into the development of circulatory control devices.

A key focus is the precise measurement of pressure, volume, and flow to construct circulatory models representing normal physiology, pathological states, and therapeutic interventions. This approach enables the establishment of simulation technologies for various treatments and has recently contributed to the development of automated therapeutic systems. We also focus on the autonomic nervous system, the central regulator of circulation, working on autonomic nerve ablation therapies and neurostimulation device development. Furthermore, by combining physics-based mathematical models with AI and integrating real-world clinical data, we are actively developing cardiovascular digital twins and software as a medical device (SaMD).

We hope this lecture will provide insight into medical devices that will play a significant role in the not-so-distant future.